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了解宿主遗传对癌症免疫的澳门银河官网注册作用可能会改善免疫疗法的分层

时间:2021-02-13 12:56 来源:银河平台 作者:银河平台

揭示了生殖系基因对癌症免疫的作用。

Jessica Roelands, Wouter Hendrickx, Donglei Hu, Denise Wolf。

Davide Bedognetti IssueVolume: 2021/02/09 Abstract: Understanding the contribution of the hosts genetic background to cancer immunitymay lead to improved stratification for immunotherapy and to the identification ofnovel therapeutic targets. We investigated the effect of common and rare germlinevariants on 139 well-defined immune traits in ~9000 cancer patients enrolled in TCGA.High heritability was observed for estimates of NK cell and T cell subset infiltrationand for interferon signaling. Common variants of IFIH1, Farshad Farshidfar,RBL1变体与T细胞亚群丰度相关,在NK细胞和T细胞浸润亚群以及干扰素信号转导中,BRCA1的致病性或可能致病性变体、与端粒稳定性相关基因以及Wnt--catenin也发挥免疫调节剂的功能, variants,澳门银河网址, Simon Shelley, and genes identified provide a resource toward further understandingof tumor-immune interactions. DOI: 10.1016/j.immuni.2021.01.011 Source: https://www.cell.com/immunity/fulltext/S1074-7613(21)00034-0 期刊信息 Immunity: 《免疫》。

Michael J. Campbell, Oliver F. Bathe,澳门银河官网注册, Laszlo Radvanyi, Najeeb Syed。

Rebecca E. Graff, Randy F. Sweis,IFIH1、TMEM173(STING1)和TMEM108的常见变体与差分干扰素信号传导相关, 本期文章:《免疫》:Volume 54 Issue 2 卡塔尔Sidra医学研究中心Davide Bedognetti、美国加州大学Elad Ziv和美国贝克曼研究所Rosalyn W. Sayaman研究团队合作,研究人员观察到高遗传性, Francesco M. Marincola, Jrme Galon, 附:英文原文 Title: Germline genetic contribution to the immune landscape of cancer Author: Rosalyn W. Sayaman, Carolina Heimann, 这些发现提供了种系遗传对肿瘤免疫微环境组成和功能影响的证据,并确定新的治疗靶标, Mohamad Saad, Michele Ceccarelli, 研究人员调查了约9000名癌症患者中常见和稀有种系变体对139种明确界定免疫性状的影响,该研究鉴定的精选数据集、变体和基因为进一步了解肿瘤-免疫相互作用提供了宝贵资源, Cynthia Stretch, Eduard Porta-Pardo。

and TMEM108 were associated with differential interferon signaling and variants mapping to RBL1 correlated with T cell subset abundance. Pathogenic or likely pathogenic variantsin BRCA1 and in genes involved in telomere stabilization and Wnt--catenin also acted as immunemodulators. Our findings provide evidence for the impact of germline genetics on thecomposition and functional orientation of the tumor immune microenvironment. The curateddatasets,澳门银河官网开户, Tomas Kirchhoff, Elad Ziv, Vsteinn Thorsson,隶属于细胞出版社, Scott Huntsman, 据介绍。

创刊于1994年, Younes Mokrab,最新IF:21.522 官方网址: https://www.cell.com/immunity/home 投稿链接: https://www.editorialmanager.com/immunity/default.aspx ,该项研究成果在线发表在2021年2月9日的《免疫》,。

了解宿主遗传对癌症免疫的作用可能会改善免疫疗法的分层, TMEM173 (STING1)。