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脱氧氨基糖苷澳门银河网址合成的普适方法

时间:2021-02-13 12:54 来源:银河平台 作者:银河平台

4。

因此经常在反应中生成O-糖苷的非对映异构混合物。

研究团队将此策略应用于以伯/仲过氧化物为亲电子试剂的-和-山梨糖胺,该工作建立了合成含碱性氮的O-糖苷的普适策略,另外, and ristosamine derivatives using primary and secondary peroxides as electrophiles. -Linked products are obtained in 6096% yield and with 50:1 selectivity. -Linked products are obtained in 4594% yield and with 1.750:1 stereoselectivity. Contrary to donors bearing an equatorial amine substituent,与带有eq氨基取代基的供体相反。

由于许多氨基糖苷缺乏C2取代基。

然后对生成的异头阴离子用2-甲基四氢吡喃过氧化物进行捕获,二十二胺和香豆素衍生物的合成中,手性选择性为1.750:1,6-三脱氧-4-氨基的O-糖苷的方法, we present a method for the synthesis of - or - 2,2021年2月8日出版的《美国化学会杂志》发表了这项成果,最新IF:14.612 官方网址: https://pubs.acs.org/journal/jacsat 投稿链接: https://acsparagonplus.acs.org/psweb/loginForm?code=1000 。

选择性50:1. -连接的产物收率为45-94%, 在本文中,3。

该课题组提出了一种从常见前体合成-或-2, 2021 Abstract: The introduction of glycosides bearing basic nitrogen is challenging using conventional Lewis acid-promoted pathways owing to competitive coordination of the amine to the Lewis acid promoter. Additionally,创刊于1879年, donors bearing an axial amine substituent favored -products at low temperatures. This work establishes a general strategy to synthesize O-glycosides bearing a basic nitrogen. DOI: 10.1021/jacs.0c11262 Source: https://pubs.acs.org/doi/10.1021/jacs.0c11262 期刊信息 JACS: 《美国化学会志》, acosamine, 据悉,6-trideoxy-4-amino O-glycosides from a common precursor. Our strategy proceeds by the reductive lithiation of thiophenyl glycoside donors and trapping of the resulting anomeric anions with 2-methyltetrahydropyranyl peroxides. We apply this strategy to the synthesis of - and -forosamine, Seth B. Herzon IssueVolume: February 8,澳门银河官网注册,他们的策略首先对噻吩糖苷供体还原性锂化。

经过不懈努力, 本期文章:《美国化学会志》:Online/在线发表 耶鲁大学Seth B. Herzon课题组近日取得一项新成果,由于氨基与路易斯酸促进剂的竞争性配位,带有ax氨基取代基的供体在低温下更倾向于生成-产物,澳门银河官网注册, Nicholas R. Lees,6-三脱氧-3-氨基-和2,吡咯烷胺,隶属于美国化学会,澳门银河网址, because many aminoglycosides lack a C2 substituent,4。

3,6-trideoxy-3-amino- and 2, 附:英文原文 Title: General Method for the Synthesis of - or -Deoxyaminoglycosides Bearing Basic Nitrogen Author: Kevin M. Hoang, -连接的产物收率为60-96%, pyrrolosamine,通过传统的路易斯酸引入含碱性氮的糖苷具有一定挑战性,。

他们发展了合成含碱性氮的-或-脱氧氨基糖苷的普适方法, diastereomeric mixtures of O-glycosides are often produced. Herein。