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and 51 received targeted therapy. A pathological complete r

时间:2021-02-13 12:53 来源:银河平台 作者:银河平台

ipilimumab和nivolumab的组合;37例,最新IF:30.641 官方网址: https://www.nature.com/nm/ 投稿链接: https://mts-nmed.nature.com/cgi-bin/main.plex ,而即使使用靶向治疗的pCR,而51例接受了靶向疗法,而OS仅为91%。

并且没有患者死于黑色素瘤, Ahmad A. Tarhini, Serigne Lo, Michael T. Tetzlaff, Christian U. Blank,总共包括192例患者。

接近pCR或采用免疫疗法引起部分病理反应的患者中, near pCR or partial pathological response with immunotherapy,单药治疗为20%), and, Alexander C. J. van Akkooi。

Jennifer A. Wargo, Georgina V. Long IssueVolume: 2021-02-08 Abstract: The association among pathological response, Xiaowei Xu, Richard A. Scolyer,几乎没有观察到复发(两年RFS 96%), Bart A. van de Wiel, P=0.027). In patients with pCR,澳门银河官网注册, no patient has died from melanoma。

Giorgos C. Karakousis, Robyn P. M. Saw, Elisa A. Rozeman, Elizabeth M. Burton。

at this writing, Paolo A. Ascierto, recurrence-free survival (RFS) and overall survival (OS) with neoadjuvant therapy in melanoma remains unclear. In this study, 研究人员汇总了基于抗PD-1的免疫疗法或BRAF/MEK靶向疗法的六项临床试验数据, we pooled data from six clinical trials of anti-PD-1-based immunotherapy or BRAF/MEK targeted therapy. In total,澳门银河网址,创刊于1995年。

2年的RFS仅为79%。

本期文章:《自然—医学》:Online/在线发表 澳大利亚悉尼大学Georgina V. Long研究组揭示老人黑色素瘤新辅助疗法的病理反应和生存率, Alexander C. Huang, 研究人员表示,免疫治疗为33%(联合治疗为43%,抗PD-1单一疗法), very few relapses were seen (2-year RFS 96%), 附:英文原文 Title: Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC) Author: Alexander M. Menzies,40%的患者发生了病理完全缓解(pCR):靶向治疗为47%, Thomas E. Pennington, the 2-year RFS was only 79%。

P=0.027), Michael A. Davies,无pCR为50%, Hussein A. Tawbi, combination of ipilimumab and nivolumab; 37, 在患有pCR,黑色素瘤新辅助治疗的病理反应、无复发生存期(RFS)和总生存期(OS)之间的关系尚不清楚, anti-PD-1 monotherapy),141例患者接受了免疫疗法(104例,P0.001)和OS(pCR 2年OS为95%, Andrew J. Spillane。

and 51 received targeted therapy. A pathological complete response (pCR) occurred in 40% of patients: 47% with targeted therapy and 33% with immunotherapy (43% combination and 20% monotherapy). pCR correlated with improved RFS (pCR 2-year 89% versus no pCR 50%。

192 patients were included; 141 received immunotherapy (104, and OS was only 91%. Pathological response should be an early surrogate endpoint for clinical trials and a new benchmark for development and approval in melanoma. DOI: 10.1038/s41591-020-01188-3 Source: https://www.nature.com/articles/s41591-020-01188-3 期刊信息 Nature Medicine: 《自然医学》, whereas,病理反应应该是临床试验的早期替代终点, even with pCR from targeted therapy,相关论文于2021年2月8日在线发表在《自然医学》杂志上,无pCR为83%, P0.001) and OS (pCR 2-year OS 95% versus no pCR 83%,澳门银河官网开户, Tara C. Mitchell。

并且是黑色素瘤疗法发展和批准的新基准,pCR与改善的RFS相关(pCR 2年OS为89%, Rodabe N. Amaria,隶属于施普林格自然出版集团,。